Malignant transformation of bronchogenic cyst revealed by 99mTc-MIBI-SPECT-Reference-Cited by-同舟云学术

Malignant transformation of bronchogenic cyst revealed by 99mTc-MIBI-SPECT

Published:2012-06 Issue:3 Volume:20 Page:347-349
ISSN:0218-4923
Container-title:Asian Cardiovascular and Thoracic Annals
language:en
Short-container-title:Asian Cardiovasc Thorac Ann

Author:

Fiorelli Alfonso¹,Rambaldi Pierfrancesco²,Accardo Marina³,Santini Mario¹

Affiliation:

1. Thoracic Surgery Unit, Second University of Naples, Naples, Italy

2. Medicine Nuclear Unit, Second University of Naples, Naples, Italy

3. Department of Pathology, Second University of Naples, Naples, Italy

Abstract

Adenocarcinoma arising from a mediastinal cyst was detected by exercise technetium-99m hexakis-2-methoxyisobutylisonitrile 99mTc-MIBI scintigraphy in a 65-year-old woman with known coronary disease. This guided further investigations and resection of the tumor which stained positive for P-glycoprotein. Three years earlier, myocardial scintigraphy was negative, probably due to down-expression of P-glycoprotein because the cells were in the early stages of carcinogenesis. After completing malignant transformation, the high P-glycoprotein expression resulted in MIBI uptake on the second myocardial scintigraphy.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,General Medicine,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1177/0218492311436258

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