Feline Gastrointestinal Lymphoma

Author:

Moore P. F.1,Rodriguez-Bertos A.2,Kass P. H.3

Affiliation:

1. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California

2. Veterinary Teaching Hospital, School of Veterinary Medicine, Complutense University, Madrid, Spain

3. Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California

Abstract

Gastrointestinal lymphomas were identified in 120 cats between 1995 and 2006. Lymphomas were classified according to the World Health Organization (WHO) scheme. Cats with mucosal T-cell lymphoma ( n = 84) predominated and had a median survival of 29 months. Mucosal T-cell lymphoma matched WHO enteropathy-associated T-cell lymphoma (EATCL) type II. Epitheliotropic T-cell infiltrates were present in 62% of cats and occurred as clusters or diffuse infiltrates of small to intermediate-sized T cells in villous and/or crypt epithelium. Similar lymphocytes infiltrated the lamina propria in distinctive patterns. Cats with transmural T-cell lymphoma ( n = 19) had a median survival of 1.5 months. Transmural T-cell lymphoma matched WHO EATCL type I. Epitheliotropic T-cell infiltrates were present in 58% of cats. Large lymphocytes ( n = 11), mostly with cytoplasmic granules (LGL–granzyme B+) ( n = 9) predominated. Transmural extension across the muscularis propria characterized the lesion. Both mucosal and transmural T-cell lymphomas were largely confined to the small intestine, and molecular clonality analysis revealed clonal or oligoclonal rearrangements of T-cell receptor-γ in 90% of cats. Cats with B-cell lymphoma ( n = 19) had a median survival of 3.5 months. B-cell lymphomas occurred as transmural lesions in stomach, jejunum, and ileo–cecal–colic junction. The majority were diffuse, large B-cell lymphomas of centroblastic type. In conclusion, T-cell lymphomas characterized by distinctive mucosal architecture, CD3 expression, and clonal expansion predominated in the feline gastrointestinal tract.

Publisher

SAGE Publications

Subject

General Veterinary

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