2-(3-Methoxyphenyl)-6, 7-methylenedioxoquinolin-4-one, a novel synthetic compound, inhibited migration and invasion in TSGH8301 human bladder cancer cells-Reference-Cited by-全球学者库

2-(3-Methoxyphenyl)-6, 7-methylenedioxoquinolin-4-one, a novel synthetic compound, inhibited migration and invasion in TSGH8301 human bladder cancer cells

Published:2010-10-07 Issue:8 Volume:30 Page:1045-1052
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Lai Kuang-Chi¹,Hsu Shu-Chun²,Yang Jai-Sing³,Kuo Chao-Lin⁴,Ip Siu-Wan²,Lai Tung-Yuan⁵,Lin Shuw-Yuan⁶,Huang Ching-Che⁷,Kuo Sheng-Chu⁸,Gibson Wood W.⁹,Chung Jing-Gung¹⁰

Affiliation:

1. Department of Surgery, China Medical University Beigang Hospital, Yunlin, Taiwan, School of Medicine, China Medical University, Taichung, Taiwan

2. School of Nutrition, China Medical University, Taichung, Taiwan

3. Department of Pharmacology, China Medical University, Taichung, Taiwan

4. School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan

5. School of Post-baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan, Department of Chinese Internal Medicine, China Medical University Hospital, Taichung, Taiwan

6. Department of Nutrition, Hung-Kuang University, Sha Lu, Taichung, Taiwan

7. Department of Chinese Medicine, China Medical University, Taichung, Taiwan

8. Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan

9. Department of Pharmacology, University of Minnesota, School of Medicine and Geriatric Research, Education and Clinical Center, VA Medical Center, Minneapolis, MN, USA

10. Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, Department of Biotechnology, Asia University, Taichung, Taiwan,

Abstract

Matrix metalloproteinases (MMPs) play an important role in the invasion, metastasis and angiogenesis of cancer cells. Many agents have been shown to inhibit the cancer cell migration and invasion by suppression of MMPs. 2-(3-Methoxyphenyl)-6,7-methylenedioxoquinolin-4-one (MMEQ) is a derivative compound synthesized from quinolin and the purpose of this study is to determine whether or not cell migration would be reduced in human bladder cancer TSGH8301 cells after MMEQ treatment. Wound healing assay and boyden chamber assay were used in cell migration and invasion determinations. Cell migration and invasion inhibited by MMEQ exerted an inhibitory effect on the sevenless homolog-1 (SOS-1), protein kinase c (PKC), extracellular signal-regulated kinase (ERK) and Rho A for causing the inhibitions of MMP-2 and -9, and then followed by the inhibitions of invasion and migration. MMEQ also affected FAK, PI3K or inhibited growth factor receptor-bound protein 2 (GRB2), nuclear factor kappaB (NF-κB), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) for cell proliferation inhibition. Therefore, MMEQ may serve as a drug in the prevention of tumor metastasis of bladder cancer in the future.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0960327110386257

Reference15 articles.

1. General mechanisms of metastasis

2. Synthesis and Antibacterial Evaluation of Certain Quinolone Derivatives

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