Protective effects of selenium against sister chromatid exchange induced by AFG 1 in human lymphocytes in vitro

Author:

Alpsoy Lokman1,Kotan Elif2,Tatar Abdulgani3,Agar Guleray4

Affiliation:

1. Department of Biology, Faculty of Science, Fatih University, Istanbul, Turkey

2. Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey

3. Department of Medical Genetics, Faculty of Medicine, Ataturk University, Erzurum, Turkey

4. Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey,

Abstract

Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic and teratogenic to different species of animals. Besides, at low concentrations, Selenium (Se4+) is antimutagenic and anticarcinogenic while it is toxic, mutagenic and carcinogenic at high concentrations. In this study, we aimed to evaluate the effect of Se4+ against aflatoxin GAFG1 (AFG1) on blood cultures in relation to induction of sister chromatid exchange (SCE). The results showed that at 0.4 and 0.8 parts per million (ppm) concentration of AFG1, the frequency of SCE increased in cultured human lymphocytes. When different concentration of Se4+ (0.08 and 8 ppm) were added to AFG1, the frequencies of SCE decreased. Howewer, when 800 ppm concentration of Se4+ together with 0.08 ppm AFG1 were added to cell division inhibited in the cultures. Results suggested that Se4+ could effectively inhibit AFG1-induced SCE. Besides, the protective role of Se4+ against AFG1-induced SCE is probably related to its doses.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

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