First International Consensus on the diagnosis and management of fibromuscular dysplasia

Author:

Gornik Heather L1,Persu Alexandre2,Adlam David34,Aparicio Lucas S5,Azizi Michel678,Boulanger Marion9,Bruno Rosa Maria10,de Leeuw Peter11,Fendrikova-Mahlay Natalia12,Froehlich James13,Ganesh Santhi K13,Gray Bruce H14,Jamison Cathlin15,Januszewicz Andrzej16,Jeunemaitre Xavier1718,Kadian-Dodov Daniella19,Kim Esther SH20,Kovacic Jason C19,Mace Pamela21,Morganti Alberto22,Sharma Aditya23,Southerland Andrew M24,Touzé Emmanuel9,van der Niepen Patricia25,Wang Jiguang26,Weinberg Ido27,Wilson Scott2829,Olin Jeffrey W19,Plouin Pierre-Francois678

Affiliation:

1. Division of Cardiovascular Medicine, University Hospitals Cleveland Medical Center and UH Harrington Heart and Vascular Institute, Cleveland, OH, USA

2. Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium

3. Department of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK

4. NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK

5. Hypertension Section, Internal Medicine Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

6. Paris Descartes University, Paris, France

7. Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Hypertension Unit, Paris, France

8. Institut national de la santé et de la recherche médicale, Centre d’Investigation Clinique 1418, Paris, France

9. Normandie Université, UNICAEN, Inserm U1237, CHU Caen Normandie, Caen, France

10. Department of Clinical and Experimental Medicine University of Pisa, Pisa, Italy

11. Department of Medicine, Maastricht University Medical Center, Maastricht, The Netherlands

12. Department of Cardiovascular Medicine, Cleveland Clinic Heart and Vascular Institute, Cleveland, OH, USA

13. Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, USA

14. University of South Carolina School of Medicine/Greenville, Greenville, SC, USA

15. Association belge de patients atteints de Dysplasie Fibromusculaire/FMD Groep België (FMD-Be), Brussels, Belgium

16. Department of Hypertension, Institute of Cardiology, Warsaw, Poland

17. APHP, Department of Genetics and Centre for Rare Vascular Diseases, Hôpital Européen Georges Pompidou, Paris, France

18. INSERM, U970 – PARCC, University Paris Descartes, Sorbonne Paris Cité, Paris, France

19. Zena and Michael A Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health; Icahn School of Medicine at Mount Sinai, New York, NY, USA

20. Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

21. Fibromuscular Dysplasia Society of America (FMDSA), North Olmsted, OH, USA

22. Centro Fisiologia Clinica e Ipertensione, Policlinico Hospital, University of Milan, Milan, Italy

23. Department of Medicine, Cardiovascular Medicine Division, University of Virginia, Charlottesville, VA, USA

24. Department of Neurology, University of Virginia, Charlottesville, VA, USA

25. Department of Nephrology & Hypertension Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium

26. Shanghai Institute of Hypertension and Center for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

27. Vascular Medicine Section and Vascular Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

28. Monash University (Central Clinical School of Medicine), Melbourne, VIC, Australia

29. Department of Renal Medicine, Alfred Health, Melbourne, VIC, Australia

Abstract

This article is a comprehensive document on the diagnosis and management of fibromuscular dysplasia (FMD), which was commissioned by the working group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). This document updates previous consensus documents/scientific statements on FMD published in 2014 with full harmonization of the position of European and US experts. In addition to practical consensus-based clinical recommendations, including a consensus protocol for catheter-based angiography and percutaneous angioplasty for renal FMD, the document also includes the first analysis of the European/International FMD Registry and provides updated data from the US Registry for FMD. Finally, it provides insights on ongoing research programs and proposes future research directions for understanding this multifaceted arterial disease.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

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