Affiliation:
1. MRC Clinical Trials Unit, University College London, London, U.K.,
Abstract
We describe a new command, artcat, that calculates sample size or power for a randomized controlled trial or similar experiment with an ordered categorical outcome, where analysis is by the proportional-odds model. artcat implements the method of Whitehead (1993, Statistics in Medicine 12: 2257–2271). We also propose and implement a new method that 1) allows the user to specify a treatment effect that does not obey the proportional-odds assumption, 2) offers greater accuracy for large treatment effects, and 3) allows for noninferiority trials. We illustrate the command and explore the value of an ordered categorical outcome over a binary outcome in various settings. We show by simulation that the methods perform well and that the new method is more accurate than Whitehead’s method.
Subject
Mathematics (miscellaneous)
Cited by
1 articles.
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1. artbin: Extended sample size for randomized trials with binary outcomes;The Stata Journal: Promoting communications on statistics and Stata;2023-03