Dentate Gyrus Immaturity in Schizophrenia

Author:

Tavitian Ayda12ORCID,Song Wei2,Schipper Hyman M.123

Affiliation:

1. Department of Neurology & Neurosurgery, Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada

2. Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada

3. Department of Medicine, McGill University, Montreal, Quebec, Canada

Abstract

Hippocampal abnormalities have been heavily implicated in the pathophysiology of schizophrenia. The dentate gyrus of the hippocampus was shown to manifest an immature molecular profile in schizophrenia subjects, as well as in various animal models of the disorder. In this position paper, we advance a hypothesis that this immature molecular profile is accompanied by an identifiable immature morphology of the dentate gyrus granule cell layer. We adduce evidence for arrested maturation of the dentate gyrus in the human schizophrenia-affected brain, as well as multiple rodent models of the disease. Implications of this neurohistopathological signature for current theory regarding the development of schizophrenia are discussed.

Funder

Canadian Institutes of Health Research

Publisher

SAGE Publications

Subject

Clinical Neurology,General Neuroscience

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