A Potential Multimodal Test for Clinical Assessment of Visual Attention in Neurological Disorders

Author:

Barone Valentina12ORCID,van Dijk Johannes P.34,Debeij-van Hall Mariette H.J.A.3,van Putten Michel J.A.M.15

Affiliation:

1. Clinical Neurophysiology (CNPH), TechMed Centre, University of Twente, Enschede, Netherlands

2. Twente Medical System International B.V. (TMSi), Oldenzaal, Netherlands

3. Academic Center for Epileptology Kempenhaeghe, Heeze, Netherlands

4. Eindhoven University of Technology, Eindhoven, Netherlands

5. Department of Clinical Neurophysiology, Medisch Spectrum Twente, Enschede, Netherlands

Abstract

Attention is an important aspect of human brain function and often affected in neurological disorders. Objective assessment of attention may assist in patient care, both for diagnostics and prognostication. We present a compact test using a combination of a choice reaction time task, eye-tracking and EEG for assessment of visual attention in the clinic. The system quantifies reaction time, parameters of eye movements (i.e. saccade metrics and fixations) and event related potentials (ERPs) in a single and fast (15 min) experimental design. We present pilot data from controls, patients with mild traumatic brain injury and epilepsy, to illustrate its potential use in assessing attention in neurological patients. Reaction times and eye metrics such as fixation duration, saccade duration and latency show significant differences (p < .05) between neurological patients and controls. Late ERP components (200–800 ms) can be detected in the central line channels for all subjects, but no significant group differences could be found in the peak latencies and mean amplitudes. Our system has potential to assess key features of visual attention in the clinic. Pilot data show significant differences in reaction times and eye metrics between controls and patients, illustrating its promising use for diagnostics and prognostication.

Funder

H2020 Marie Skłodowska-Curie Actions

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology,General Medicine

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