CYP2C19Genotype Is a Major Factor Contributing to the Highly Variable Pharmacokinetics of Voriconazole

Author:

Weiss Johanna,ten Hoevel Magdalena Maria,Burhenne Jürgen,Walter-Sack Ingeborg,Hoffmann Michael Marcus,Rengelshausen Jens,Haefeli Walter E.,Mikus Gerd

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference39 articles.

1. FDA Antiviral Drugs Advisory Committee. Briefing Document for Voriconazole (Oral and Intravenous Formulations) October 4, 2001 http:www.fda.govohrmsdocketsac01briefing3792b201Pfizerpdf

2. Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole;Hyland;Drug Metab Dispos,2003

3. The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human;Roffey;Drug Metab Dispos,2003

4. Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes;Murayama;Biochem Pharmacol,2007

5. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily;Goldstein;Br J Clin Pharmacol,2001

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