Epithelial-Mesenchymal Interactions in the Development of Salivary Glands

Author:

Cutler Leslie S.1,Gremski Waldemiro2

Affiliation:

1. Administration & Research, LM 068, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030

2. Departmento de Ciencias Morfologicas, Setor de Ciencias Biologicas, Universidade Federal do Parana, 80.000 Curitiba - Parana, Brazil

Abstract

The full expression of both morphogenesis and secretory cell differentiation in salivary glands is modulated or controlled, at least in part, by interactions between the salivary epithelium and the surrounding mesenchyme. Salivary gland morphogenesis and cytodifferentiation are partially linked but independently regulated processes. This presentation reviews the information that establishes the role of various extracellular matrix molecules and direct epithelial-mesenchymal interactions in the induction, control, and maintenance of morphogenesis and secretory cell differentiation in salivary glands.

Publisher

SAGE Publications

Subject

General Dentistry,Otorhinolaryngology

Reference62 articles.

1. Lawson, K.A., The role of mesenchyme in the morphogenesis and functional differentiation of rat salivary epithelium, J. Embryol. Exp. Morph., 27, 497, 1972.

2. Lawson, K.A., Mesenchyme specificity in rodent salivary gland development: the response of salivary epithelium to lung mesenchyme in vitro, J. Embryol. Exp. Morph., 32, 469, 1974.

3. Cutler, L.S., The role of extracellular matrix in the morphogenesis and differentiation of salivary glands, Adv. Dent. Res., in press.

4. Cytodifferentiation of the acinar cells of the rat submandibular gland

5. Autonomic receptors in the developing submandibular glands of neonatal rats

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