Molecular Biology of Human Oral Cancer

Author:

Wong D.T.W.1,Todd R.2,Tsuji T.1,Donoff R.B.2

Affiliation:

1. Laboratory of Molecular Pathology, Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, Massachusetts 02115

2. Laboratory of Molecular Pathology, Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, Massachusetts 02115, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital

Abstract

The application of molecular biological tools to the study of cancer has significantly advanced the field of human cancer research. Such study has demonstrated the involvement of two classes of highly conserved cellular genes in the malignant transformation process: oncogenes and tumor suppressor genes. Despite these advances in the molecular biology of human cancers, our understanding of human oral cancer lags behind that of cancer of other body sites. This review attempts to assess the current status of the molecular biology of human oral cancer.

Publisher

SAGE Publications

Subject

General Dentistry,Otorhinolaryngology

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