Suspected acquired hypocobalaminaemic encephalopathy in a cat: resolution of encephalopathic signs and MRI lesions subsequent to cobalamin supplementation

Author:

Simpson Katherine1,Battersby Ian1,Lowrie Mark1

Affiliation:

1. Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hitchin SG5 3HR, UK

Abstract

Presenting signs and initial investigations: An 8-year-old female spayed British shorthair cat was presented with a history of waxing and waning neurological signs. Neuroanatomical localisation was consistent with a diffuse forebrain disease. Blood ammonia concentration was increased. Abdominal ultrasonography and a bile acid stimulation test were normal. Magnetic resonance imaging (MRI) revealed hyperintense, bilaterally symmetrical, diffuse lesions on T2-weighted sequences, predominantly, but not exclusively, affecting the grey matter. Serum cobalamin (vitamin B12) concentration was low. Hypocobalaminaemia resulting in a urea cycle abnormality was considered a likely cause of the hyperammonaemia. Treatment: Daily cobalamin injections resulted in a rapid clinical improvement. Eight weeks into treatment neurological examination was unremarkable and there was complete resolution of the MRI lesions. Clinical importance: This is the first reported case of acquired feline hypocobalaminaemia resulting in an encephalopathy. Additionally, this case is unique in describing reversible brain MRI abnormalities in a cobalamin-deficient companion animal.

Publisher

SAGE Publications

Subject

Small Animals

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1. Effect of oral or subcutaneous administration of cyanocobalamin in hypocobalaminemic cats with chronic gastrointestinal disease or exocrine pancreatic insufficiency;Journal of Veterinary Internal Medicine;2024-09-13

2. Hyperammonaemia in cats;Companion Animal;2024-04-02

3. Vitamin B12 in Cats: Nutrition, Metabolism, and Disease;Animals;2023-04-26

4. Serum cobalamin concentrations in dogs infected with canine parvoviral enteritis;Journal of the American Veterinary Medical Association;2022-02-02

5. What Is Your Diagnosis?;Journal of the American Veterinary Medical Association;2021-08-01

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