Tenofovir alafenamide fumarate-Reference-Cited by-同舟云学术

Tenofovir alafenamide fumarate

Published:2022-03-07 Issue:2 Volume:27 Page:135965352110676
ISSN:1359-6535
Container-title:Antiviral Therapy
language:en
Short-container-title:Antiviral Therapy

Author:

Lee William A¹^ORCID,Cheng Andrew K²

Affiliation:

1. San Francisco, CA, USA

2. Akero Therapeutics, South San Francisco, CA, USA

Abstract

Tenofovir alafenamide fumarate is a lipophilic prodrug of tenofovir which is preferentially metabolized in lymphatic tissue resulting in high concentrations of tenofovir (TFV) and its active diphosphate metabolite inside the cells that replicate HIV. Due to its selectivity for these tissues, lower total doses of TAF can be administered relative to tenofovir disoproxil fumarate (TDF) which results in improved bone and renal biomarkers. Tenofovir alafenamide fumarate has become the “backbone” of multiple combination products for the treatment of HIV, combined with emtricitabine for PreP and as a monotherapy for the treatment or HBV.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/13596535211067600

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