Combined Platelet Rich Plasma and Amniotic membrane in the treatment of Perforated Corneal Ulcers

Abstract

Purpose To report the outcomes of using synthetic amniotic membrane with platelet rich plasma for the primary management of corneal perforations. Setting Ophthalmology department. Faculty of Medicine, Minia University, Minia, Egypt Methods A case series of 10 patients diagnosed with corneal perforation underwent emergency surgical procedure for repair of the perforation through the implantation of synthetic amniotic membrane with platelet-rich plasma clot under it and the application of platelet-rich plasma eye drops, with a follow up period of up to 4 weeks. Results All cases demonstrated formation of adequate intraocular pressure digitally, within the first 7 days, and all cases showed complete sealing of the corneal perforation within the 4 weeks follow up period, mild symptoms were reported only in the 1st postoperative week like foreign body sensation and lacrimation. 3 of the treated patients underwent penetrating keratoplasty after 6 months with satisfactory visual outcomes. Conclusion The combination of amniotic membrane implant and platelet rich plasma in both the clot and eye drop forms is an effective and easy accessible method for the primary management of corneal perforations