Affiliation:
1. Division of Pediatric Nephrology, Children's Hospital, Ruperto-Carolus University, Heidelberg, Germany
Abstract
♦ Objectives To evaluate the distribution of peritonitis incidence and assess the usefulness of patient-specific peritonitis rates in children. ♦ Design 49 children on automated peritoneal dialysis (PD) followed during a 2-year observation period. ♦ Setting Single-center, academic children's hospital. ♦ Patients 49 children aged 2 months to 18 years; 24 prevalent, 25 incident during the observation period. Cumulative observation time was 639 patient-months. ♦ Main Outcome Measures Cohort-specific peritonitis incidence, median patient-specific peritonitis incidence, mean peritonitis incidence by gamma-Poisson (negative binomial) modeling, peritonitis-free survival by Kaplan–Meier life-table analysis. ♦ Results 68 new peritonitis episodes and 21 relapses occurred in 27 patients. The distribution of patient-specific peritonitis incidence was bimodal, with a large group experiencing no or very few episodes, and another cluster around 1 episode per 6 – 9 months. Overall cohort-specific peritonitis incidence was 1.28, median subject-specific incidence 0.99, and mean incidence according to negative binomial modeling 1.04 (95% confidence interval 1.02 – 1.06) episodes per patient-year. Median peritonitis-free survival time was 6.9 months. In those patients who developed peritonitis, subject-specific peritonitis incidence was inversely correlated with patient age ( r = –0.42, p < 0.05) and duration of chronic PD at last observation ( r = –0.42, p < 0.05). ♦ Conclusions Since the distribution of peritonitis in children is non-Gaussian, the average risk of peritonitis is more accurately expressed by the median of the individual subject-specific peritonitis rates or by the mean incidence estimate obtained by the negative binomial distribution model. The assignment of a personal peritonitis risk to each patient permits risk factor analysis by routine statistical methods, even in smaller populations.
Subject
Nephrology,General Medicine
Cited by
23 articles.
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1. Peritoneal Dialysis in Children;Nolph and Gokal's Textbook of Peritoneal Dialysis;2023
2. Infectious Complications of Peritoneal Dialysis in Children;Pediatric Dialysis;2021
3. Peritoneal Dialysis in Children;Nolph and Gokal's Textbook of Peritoneal Dialysis;2021
4. ISPD Catheter-Related Infection Recommendations: 2017 Update;Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis;2017-03
5. ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment;Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis;2016-09