Association between insulin resistance and risk of atrial fibrillation in non-diabetics

Author:

Lee Yonggu1,Cha Sung Joo2,Park Jung-Hwan3,Shin Jeong-Hun1,Lim Young-Hyo2,Park Hwan-Cheol1,Shin Jinho2,Kim Chun Ki4,Park Jin-Kyu2

Affiliation:

1. Division of Cardiology, Hanyang University Guri Hospital, Republic of Korea

2. Division of Cardiology, Hanyang University Medical Center, Republic of Korea

3. Division of Endocrinology and Metabolism, Hanyang University Medical Center, Republic of Korea

4. Department of Medicine, Hanyang University College of Medicine, Republic of Korea

Abstract

Aims Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population. Methods Between 2001–2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation. Results Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14–2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1–2.5, and then plateaued afterwards (p = 0.031). Conclusion There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Epidemiology

Reference22 articles.

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