Metabolic syndrome: pathophysiology, management, and modulation by natural compounds

Author:

Rochlani Yogita1,Pothineni Naga Venkata2,Kovelamudi Swathi3,Mehta Jawahar L.3

Affiliation:

1. Division of Cardiovascular Medicine, Westchester Medical Center, Valhalla, NY, USA

2. Division of Cardiovascular Medicine, Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, 4301 W. Markham St. #532, Little Rock, AR 72205, USA

3. Division of Cardiovascular Medicine, Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, Little Rock, AR, USA

Abstract

Metabolic syndrome (MetS) represents a cluster of metabolic abnormalities that include hypertension, central obesity, insulin resistance, and atherogenic dyslipidemia, and is strongly associated with an increased risk for developing diabetes and atherosclerotic and nonatherosclerotic cardiovascular disease (CVD). The pathogenesis of MetS involves both genetic and acquired factors that contribute to the final pathway of inflammation that leads to CVD. MetS has gained significant importance recently due to the exponential increase in obesity worldwide. Early diagnosis is important in order to employ lifestyle and risk factor modification. Here, we review the epidemiology and pathogenesis of MetS, the role of inflammation in MetS, and summarize existing natural therapies for MetS.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Cardiology and Cardiovascular Medicine

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