Renal Amyloidosis Secondary to Monoclonal Gammopathy of Renal Significance in a Young Patient: A Case Report

Abstract

Monoclonal gammopathy of renal significance (MGRS), a subtype of plasma cell disorder, usually occurs in individuals >50 years. Amyloid light chain (AL)-associated primary amyloidosis can occur in both young and elderly individuals. However, the progression of AL amyloidosis is usually reported in aged MGRS patients several years after its onset. Herein, we report the case of a young patient with persistent proteinuria and bilateral edema. Histopathological examination confirmed a differential diagnosis of MGRS. Further, Congo red and immunohistochemical staining of the renal biopsy confirmed the presence of lambda-light-chain-derived amyloid deposits in the affected kidney. We report the predominance of MGRS-associated renal amyloidosis in a young patient, conflicting with the age criteria. This case report highlights age as an independent risk factor, signifying the need to diagnose amyloidosis in young people.