Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages

Author:

Chang Chia-Yu123ORCID,Ting Hsiao-Chien1,Liu Ching-Ann123ORCID,Su Hong-Lin4,Chiou Tzyy-Wen5,Harn Horng-Jyh16ORCID,Lin Shinn-Zong17ORCID,Ho Tsung-Jung8910

Affiliation:

1. Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

2. Department of Medical Research, Hualien Tzu Chi Hospital, Hualien, Taiwan

3. Neuroscience Center, Hualien Tzu Chi Hospital, Hualien, Taiwan

4. Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan

5. Department of Life Science, National Dong Hwa University, Hualien, Taiwan

6. Department of Pathology, Hualien Tzu Chi Hospital and Tzu Chi University, Hualien, Taiwan

7. Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, Taiwan

8. Department of Chinese Medicine, Hualien Tzu Chi Hospital, Hualien, Taiwan

9. Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Hualien, Taiwan

10. School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan

Abstract

Human pluripotent stem cells (hPSCs) are sources of several somatic cell types for human developmental studies, in vitro disease modeling, and cell transplantation therapy. Improving strategies of derivation of high-purity specific neural and glial lineages from hPSCs is critical for application to the study and therapy of the nervous system. Here, we will focus on the principles behind establishment of neuron and glia differentiation methods according to developmental studies. We will also highlight the limitations and challenges associated with the differentiation of several “difficult” neural lineages and delay in neuronal maturation and functional integration. To overcome these challenges, we will introduce strategies and novel technologies aimed at improving the differentiation of various neural lineages to expand the application potential of hPSCs to the study of the nervous system.

Funder

Hualien Tzu Chi Hospital

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

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