Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report-Reference-Cited by-同舟云学术

Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report

Published:2021-01-01 Issue: Volume:30 Page:096368972097714
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Fang Liu¹,Meikuang Lim²,Ye Guo¹,Xiaojuan Chen¹,Wenyu Yang¹,Min Ruan¹,Lixian Chang¹,Weiqiang Wang²,Zhibo Han¹²,Zhongchao Han¹²,Xiaofan Zhu¹

Affiliation:

1. Institute of Hematology and Blood Diseases Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, China

2. National Engineering Research Center of Cell Products, Tianjin AmCellGene Engineering Co., Ltd, Tianjin, China

Abstract

Here we presented a case of a 19-month-old boy who developed severe aplastic anemia postacute hepatitis. He was treated successfully with the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) infusion and cyclosporine A (CsA). The boy achieved both hematopoietic recovery and normal lymphocyte proportion. So far, his condition still remains stable. To our knowledge, there is a rare previous report on the utility of MSCs infusion for the treatment of hepatitis-associated aplastic anemia (HAAA). Considering the efficacy, safety, and strong operability, particularly for pediatric patient, the infusion of UC-MSCs combined with CsA could be an effective alternative for the treatment of HAAA.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/0963689720977144

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1. Hepatitis-associated Aplastic Anemia;Journal of Pediatric Gastroenterology & Nutrition;2022-09-06