Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates-Reference-Cited by-同舟云学术

Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates

Published:1994-07 Issue:4 Volume:3 Page:339-343
ISSN:0963-6897
Container-title:Cell Transplantation
language:en
Short-container-title:Cell Transplant

Author:

Wake M. Conley¹,Patrick Charles W.¹,Mikos Antonios G.¹

Affiliation:

1. Department of Chemical Engineering and Institute of Biosciences and Bioengineering, Cox Laboratory for Biomedical Engineering, Rice University, P.O. Box 1892, Houston, TX 77251, USA

Abstract

The feasibility of developing biodegradable polymer scaffolds to engineer tissues was investigated by studying the effects of pore size on the dynamics of fibrovascular tissue ingrowth. Tissue advanced into amorphous poly(l-lactic acid) porous substrates faster as the pore diameter increased. Porous cylindrical devices of 13.5 mm diameter, 5 mm thickness, and approximately 500 μm pore size were filled completely by tissue 5 days postimplantation. Although prevascularized devices possessed minimal void volume for cell seeding to regenerate metabolic organs, they hold promise in the regeneration of tubular tissues by relying on the epithelization of prevascularized grafts.

Publisher

SAGE Publications

Subject

Transplantation,Cell Biology,Biomedical Engineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/096368979400300411

Reference15 articles.

1. Hepatocyte culture on biodegradable polymeric substrates

2. Neocartilage formationin vitro andin vivo using cells cultured on synthetic biodegradable polymers

3. Tissue Engineering

4. Use of polyphosphazenes for skeletal tissue regeneration

5. Covalently Attached GRGD on Polymer Surfaces Promotes Biospecific Adhesion of Mammalian Cells

Cited by 277 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Engineering periodontal tissue interfaces using multiphasic scaffolds and membranes for guided bone and tissue regeneration;Biomaterials Advances;2024-02

2. Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis;iScience;2023-11

3. Negative pressure wound therapy: Where are we in 2022?;OTA International: The Open Access Journal of Orthopaedic Trauma;2023-07

4. A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling;Bioactive Materials;2023-01

5. Ceramic scaffolds for biomaterials applications;Advanced Ceramic Coatings for Biomedical Applications;2023