Hydroquinone, a benzene metabolite, and leukemia: A case report and review of the literature-Reference-Cited by-同舟云学术

Hydroquinone, a benzene metabolite, and leukemia: A case report and review of the literature

Published:2011-04-21 Issue:1 Volume:28 Page:64-73
ISSN:0748-2337
Container-title:Toxicology and Industrial Health
language:en
Short-container-title:Toxicol Ind Health

Author:

Regev Lee¹,Wu Michael¹,Zlotolow Ronald¹,Brautbar Nachman²

Affiliation:

1. Nachman Brautbar, M.D., Inc., Los Angeles, CA, USA

2. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Abstract

Hydroquinone is a phenolic metabolite of benzene, a known human carcinogen. Hydroquinone is widely used in the industry. We report a case of a 43-year-old male diagnosed with antecedent myelodysplastic syndrome and acute myeloid leukemia following 16 years of occupational exposure to hydroquinone in radiographic developer solution. Cytogenetic studies revealed aberrations in chromosome 5 and chromosome 7. We review the literature on hydroquinone as a potential cause of hematolymphatic cancers and discuss the role of hydroquinone as a genotoxic and leukemogenic agent.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0748233711404037

Reference49 articles.

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