Application of metalloporphyrin sensitizers for the treatment or diagnosis of tumors

Author:

Luo Hongyu12,Yu Wenmei12,Chen Si12,Wang Zhenyu3,Tian Zejie12,He Jun3,Liu Yunmei12ORCID

Affiliation:

1. Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, People’s Republic of China

2. Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, People’s Republic of China

3. Institute of Chemistry & Chemical Engineering, University of South China, Hengyang, People’s Republic of China

Abstract

At present, metalloporphyrin compounds demonstrate three main uses as anticancer sensitizers: (1) photosensitizers, (2) photothermal conversion agents, and (3) ultrasound sensitizers. Developing efficient sensitizers for cancer with excellent controllability and biocompatibility is an important goal of oncology medicine. Because of the different structural diversity of anticancer sensitizers, such sensitizers are used for treating cancers by employing a variety of tumor treatment methods such as mature photodynamic therapy, commonly used clinically photothermal therapy and promising sonodynamic therapy. Among the many sensitizers, metalloporphyrin-complex sensitizers attract wide attention due to their excellent performance in tumor treatment and diagnosis. This review briefly describes some metalloporphyrin anticancer drugs and diagnostic agents related to photodynamic, photothermal and sonodynamic therapy, and discusses the roles of metal atoms in these drugs.

Funder

education department of hunan province

hunan provincial innovation foundation for postgraduate

the Hunan Provincial Innovation Foundation For Postgraduate

the University of South China Students Innovation and Entrepreneurship Training Program

Publisher

SAGE Publications

Subject

General Chemistry

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