Affiliation:
1. Department of Burns & Wound Care Centre, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
2. The Key Laboratory of Trauma and Burns of Zhejiang University, Hangzhou, Zhejiang, China
Abstract
Skin and skin appendages are vulnerable to injury, requiring rapidly reliable regeneration methods. In recent years, 3D bioprinting has shown potential for wound repair and regeneration. 3D bioprinting can be customized for skin shape with cells and other materials distributed precisely, achieving rapid and reliable production of bionic skin substitutes, therefore, meeting clinical and industrial requirements. Additionally, it has excellent performance with high resolution, flexibility, reproducibility, and high throughput, showing great potential for the fabrication of tissue-engineered skin. This review introduces the common techniques of 3D bioprinting and their application in skin tissue engineering, focusing on the latest research progress in skin appendages (hair follicles and sweat glands) and vascularization, and summarizes current challenges and future development of 3D skin printing.
Funder
national key research and development program of china
basic public welfare research program of zhejiang province
national natural science foundation of china
Subject
Biomedical Engineering,Biomaterials,Medicine (miscellaneous)
Cited by
143 articles.
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