Pushing the agenda for intravenous push administration in outpatient parenteral antimicrobial therapy

Author:

Johnson Tanner M.1ORCID,Whitman Webster Leah C.2,Mehta Meera3,Johnson Jessica E.4,Cortés-Penfield Nicolás5,Rivera Christina G.1

Affiliation:

1. Department of Pharmacy, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA

2. Department of Pharmacy, Mayo Clinic, Jacksonville, FL, USA

3. West Virginia University Hospitals, Morgantown, WV, USA

4. Department of Medicine, Section of Infectious Diseases, West Virginia University, Morgantown, WV, USA

5. Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA

Abstract

Intravenous push (IVP) antimicrobial administration refers to rapid bolus infusion of medication. This drug delivery method offers improved patient convenience, superior patient and nursing satisfaction, and cost savings when used in outpatient parenteral antimicrobial therapy (OPAT). Antimicrobial agents must demonstrate optimal physiochemical and pharmacologic characteristics, as well as sufficient syringe stability, to be administered in this manner. Additionally, impacts on medication tolerability, patient safety, and effectiveness must be considered. This narrative review summarizes the available data and practical implications of IVP administration of antimicrobials in the OPAT setting.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Infectious Diseases

Reference57 articles.

1. 2018 Infectious Diseases Society of America Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial Therapya

2. A Primer on Home Infusion Administration Methods

3. Intravenous Push Administration of Antibiotics: Literature and Considerations

4. Institute for Safe Medication Practices. ISMP safe practice guidelines for adult IV push medications. Institute for Safe Medication Practices website, https://www.ismp.org/guidelines/iv-push (2015, accessed 15 January 2023).

5. Tolerability of hypertonic injectables

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