Association of Dementia and Peptic Ulcer Disease-Reference-Cited by-同舟云学术

Association of Dementia and Peptic Ulcer Disease

Published:2016-07-10 Issue:5 Volume:31 Page:389-394
ISSN:1533-3175
Container-title:American Journal of Alzheimer's Disease & Other Dementiasr
language:en
Short-container-title:Am J Alzheimers Dis Other Demen

Author:

Hsu Chih-Chao¹,Hsu Yi-Chao²,Chang Kuang-Hsi³,Lee Chang-Yin⁴,Chong Lee-Won⁵,Lin Cheng-Li⁶,Kao Chia-Hung⁷⁸⁹

Affiliation:

1. Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

2. Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan

3. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan

4. School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan

5. Division of Hepatology and Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan

6. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

7. College of Medicine, China Medical University, Taichung, Taiwan

8. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

9. Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Abstract

Objective: We determine the association between dementia and the subsequent peptic ulcer disease (PUD). Methods: We identified patients with diagnosed dementia in the Taiwan National Health Insurance Research Database. A comparison cohort without dementia was frequency-matched by age, sex, and comorbidities, and the occurrence of PUD was evaluated in both cohorts. Results: The dementia and control cohort consisted of 6014 patients with dementia and 17 830 frequency-matched patients without dementia, respectively. The incidence of PUD (hazard ratio, 1.27; 95% confidence interval, 1.18-1.37; P < .001) was higher among patients with dementia. Cox models showed that being female, diabetes mellitus, chronic kidney disease, coronary artery disease, and chronic obstructive pulmonary disease were independent risk factors for PUD in patients with dementia. Conclusion: Dementia might increase the risk of developing PUD.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/1533317515617546

Reference31 articles.

1. Activities of daily living and quality of life across different stages of dementia: a UK study

2. Empfehlungen zur Diagnostik und Therapie der behavioralen und psychologischen Symptome der Demenz (BPSD)

3. A claims data-based comparison of comorbidity in individuals with and without dementia

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