Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study-Reference-Cited by-同舟云学术

Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study

Published:2023-01 Issue: Volume:38 Page:
ISSN:1533-3175
Container-title:American Journal of Alzheimer's Disease & Other Dementias®
language:en
Short-container-title:Am J Alzheimers Dis Other Demen

Author:

Chen Cheng¹²,Yang Keming³,Nan Hongmei⁴,Unverzagt Frederick⁵,McClure Leslie A.⁶,Irvin Marguerite R.⁷,Judd Suzanne⁸,Cushman Mary⁹,Kamin Mukaz Debora⁹,Klaunig James E.¹⁰,D'Alton Mary E.¹,Kahe Ka¹²^ORCID

Affiliation:

1. Department of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University, New York, NY, USA

2. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

3. Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital & Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA

4. Department of Global Health, Richard M. Fairbanks School of Public Health, Indiana University–Purdue University Indianapolis, Indianapolis, IN, USA

5. Department of Psychiatry, School of Medicine, Indiana University, Indianapolis, IN, USA

6. Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA

7. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA

8. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA

9. Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA

10. Department of Environmental and Occupational Health, School of Public Health, Indiana University–Bloomington, Bloomington, IN, USA

Abstract

Introduction We examined the associations of baseline telomere length (TL) and TL change with cognitive function over time in older US adults, as well as differences by sex and race. Methods A total of 1820 cognitively healthy individuals (median baseline age: 63 years) were included. Telomere length was measured using qPCR-based method at baseline and among 614 participants in the follow-up examination 10 years later. Cognitive function was assessed by a four-test battery every 2 years. Results In multivariable-adjusted linear mixed models, longer baseline TL and smaller attrition/lengthening of TL over time were associated with better Animal Fluency Test score. Longer baseline TL was also linearly associated with better Letter Fluency Test score. The observed associations were consistently more pronounced in women than men and in Black compared to White participants. Discussion Telomere length may be a biomarker that predicts long-term verbal fluency and executive function, particularly in women and Black Americans.

Funder

National Institutes of Health

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/15333175231175797

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