Effect of Acupuncture on the Brain in Children With Spastic Cerebral Palsy Using Functional Neuroimaging (fMRI)

Author:

Wu Yun1,Jin Zhen2,Li Ke2,Lu Zhong-Li1,Wong Virginia3,Han Tong-Li1,Zheng Hua1,Caspi Opher4,Liu Gang2,Zeng Ya-Wei2,Zou Li-Ping5

Affiliation:

1. Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing

2. Center for fMRI & Department of Radiology, No. 306 Hospital of PLA, Beijing

3. Division of Neurodevelopmental Paediatrics, Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, China

4. The Recanati Center for Medicine and Research, and the Section of Integrative Medicine, Rabin Medical Center (Beilinson Campus), and the Tel-Aviv Sourasky Faculty of Medicine, Israel

5. Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing, and , Department of Pediatrics, Chinese PLA General Hospital (No. 301 Hospital of PLA), Beijing, China,

Abstract

We study the effect of acupuncture on brain activation patterns in children with cerebral palsy using functional magnetic resonance imaging (fMRI). fMRI of the whole brain was performed in 11 children with cerebral palsy and 10 healthy children during stimulation of a common acupoint in Traditional Medicine [Liv3 (Taichong)] on the left foot. We use both twisting and nontwisting methods with a blocked paradigm on a 2.0 Tesla MRI scanner. Functional data were analyzed by using Statistical Parametric Mapping software (SPM 99). Both signal increase and decrease in various regions of the brain were found in both groups of children. However, the pattern was different for the 2 groups, especially with decreases in signal regions. We suggest that the observed differences between children with cerebral palsy and healthy children with the stimulation of acupoint Liv3 might be due to blockage of the liver meridian in children with cerebral palsy.

Publisher

SAGE Publications

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

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