Affiliation:
1. Clinical Medical College, Yangzhou University, Yangzhou, China
2. Clinical Medical College, Dalian Medical University, Dalian, China
3. Department of General Surgery, Institute of General Surgery, Clinical Medical College, Northern Jiangsu People’s Hospital, Yangzhou University, Yangzhou, China
Abstract
Colorectal cancer (CRC) is the third most common cancer in the world, and its incidence rate and mortality are on the rise in many countries. In recent years, with the improvement of economic conditions, people’s living habits have changed, including lack of physical activity, poor diet patterns and circadian rhythm disorder. These risk factors can change the colon environment and the composition of intestinal microbiota. This state is called intestinal imbalance, which increases the risk of cancer. Probiotics, a class of microorganisms that help maintain gut microbial homeostasis and alleviate dysbiosis, may help prevent inflammation and colorectal cancer. These probiotics inhibit or ameliorate the effects of dysbiosis through the production of short-chain fatty acids (SCFAs), modulation of immunity, maintenance of the intestinal epithelial barrier, pro-apoptotic mechanisms, and other mechanisms. This review aims to explain the interaction between probiotics, the gut microenvironment and the gut microbiota, and summarize reports on the possibility of probiotics in the prevention and treatment of colorectal cancer.
Funder
High-level talent “six one projects” top talent scientific research project of Jiangsu Province
the Graduate Research and Practice Innovation Plan of Graduate Education Innovation Project in Jiangsu Province
Training Project of Key Talents of Youth Medicine in Jiangsu province, China
the Social Development Project of Yangzhou, Jiangsu Province
the Social Development-Health Care Project of Yangzhou, Jiangsu Province
the Academic Science and Technology Innovation Fund for College Students
Social development project of key R & D plan of Jiangsu Provincial Department of science and technology
the Key Disease Standardization Diagnosis and Treatment Project in Jiangsu province
Graduate Research- Innovation Project in Jiangsu province