The evolving landscape of criteria for evaluating tumor response in the era of cancer immunotherapy: From Karnofsky to iRECIST

Author:

Inno Alessandro1,Lo Russo Giuseppe2,Salgarello Matteo3,Corrao Giulia2,Casolino Raffaella1,Galli Giulia2,Modena Alessandra1,Romano Luigi4,Pusceddu Sara2,Greco Francesca Gabriella5,Garassino Marina Chiara1,Gori Stefania1

Affiliation:

1. Unità di Oncologia Medica, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy

2. Dipartimento di Oncologia Medica, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

3. Unità di Medicina Nucleare, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy

4. Unità di Radiologia, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy

5. Unità di Radiologia Diagnostica e Interventistica, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

Abstract

The objective response is an important endpoint to evaluate clinical activity of new anticancer drugs. Standardized criteria for evaluating response are needed for comparing results of different trials and represent the basis for advances in cancer therapy. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 are the most used in clinical practice and in clinical trials; however, they are not able to capture atypical responses seen with immunotherapy drugs. We describe the evolution of response criteria with a special focus on the immune-related criteria.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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