Impact of inter-observer variability on first axillary level dosimetry in breast cancer radiotherapy: An AIRO multi-institutional study-Reference-Cited by-同舟云学术

Impact of inter-observer variability on first axillary level dosimetry in breast cancer radiotherapy: An AIRO multi-institutional study

Published:2023-09-09 Issue:6 Volume:109 Page:570-575
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Leonardi Maria Cristina¹,Pepa Matteo¹^ORCID,Zaffaroni Mattia¹^ORCID,Vincini Maria Giulia^ORCID,Luraschi Rosa²,Vigorito Sabrina²,Morra Anna¹,Dicuonzo Samantha¹^ORCID,Mazzola Giovanni Carlo¹,Gerardi Marianna Alessandra¹,Zerella Maria Alessia¹,Cante Domenico³,Petrucci Edoardo⁴,Borzì Giuseppina⁵,Marrocco Maristella⁶,Chieregato Matteo⁷,Iadanza Luciano⁸,Lobefalo Francesca⁹,Valenti Marco¹⁰,Cavallo Anna¹¹,Russo Serenella¹²,Guernieri Marika¹³,Malatesta Tiziana¹⁴,Meaglia Ilaria¹⁵,Liotta Marco¹⁶,Palumbo Isabella¹⁷,Marcantonini Marta¹⁸,Mezzenga Emilio¹⁹,Falivene Sara²⁰,Arrichiello Cecilia²¹,Barbero Maria Paola²²,Ivaldi Giovanni Battista¹⁵,Catalano Gianpiero²³,Vidali Cristiana²⁴,Giannitto Caterina²⁵,Ciabattoni Antonella²⁶^ORCID,Meattini Icro²⁷²⁸,Aristei Cynthia¹⁷,Orecchia Roberto²⁹,Cattani Federica²,Jereczek-Fossa Barbara Alicja¹³⁰

Affiliation:

1. Division of Radiation Oncology, Istituto Europeo di Oncologia, IRCCS, Milano, Italy

2. Unit of Medical Physics, Istituto Europeo di Oncologia, IRCCS, Milano, Italy

3. Radiotherapy Department, ASL TO4 Ivrea Community Hospital, Ivrea, Italy

4. Unit of Medical Physics, ASL TO4 Ivrea Community Hospital, Ivrea, Italy

5. Unit of Medical Physics, REM Radioterapia, Viagrande, Italy

6. Unit of Medical Physics, Campus Bio-Medico University, Roma, Italy

7. Unit of Medical Physics, Fondazione Poliambulanza, Brescia, Italy

8. Unit of Medical Physics, Azienda Ospedaliera di Rilievo Nazionale San Pio, Benevento, Italy

9. Radiotherapy and Radiosurgery Department, Humanitas Clinical and Research Centre IRCCS, Milano, Italy

10. Unit of Medical Physics, Ospedali Riuniti Umberto I, G.M. Lancisi, G. Salesi, Ancona, Italy

11. Unit of Medical Physics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy

12. Unit of Medical Physics, AUSL Toscana Centro, Ospedale Santa Maria Annunziata, Firenze, Italy

13. Medical Physics Unit, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy

14. Unit of Medical Physics, Ospedale Fatebenefratelli Isola Tiberina - Gemelli Isola, Roma, Italy

15. Department of Radiation Oncology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy

16. Unit of Medical Physics, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy

17. Radiation Oncology section, University of Perugia and Perugia General Hospital, Perugia, Italy

18. Medical Physics Unit, University of Perugia and Perugia General Hospital, Perugia, Italy

19. Medical Physics Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori", Meldola, Italy

20. Department of Radiotherapy, ASL Napoli1 Centro – Ospedale del Mare, Napoli, Italy

21. Unit of Radiotherapy, Istituto Nazionale Tumori – IRCCS – Fondazione G. Pascale, Napoli, Italy

22. Unit of Medical Physics, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy

23. Department of Radiotherapy, IRCCS MultiMedica, Sesto San Giovanni, Italy

24. Department of Radiation Oncology, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy

25. Division of Radiology, Istituto Europeo di Oncologia IRCCS, Milano, Italy

26. Department of Radiotherapy, San Filippo Neri Hospital, ASL Roma 1, Roma, Italy

27. Radiation Oncology Unit - Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy

28. Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Firenze, Italy

29. Scientific Direction, Istituto Europeo di Oncologia, IRCCS, Milano, Italy

30. Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy

Abstract

This study quantified the incidental dose to the first axillary level (L1) in locoregional treatment plan for breast cancer. Eighteen radiotherapy centres contoured L1-L4 on three different patients (P1,2,3), created the L2-L4 planning target volume (single centre planning target volume, SC-PTV) and elaborated a locoregional treatment plan. The L2-L4 gold standard clinical target volume (CTV) along with the gold standard L1 contour (GS-L1) were created by an expert consensus. The SC-PTV was then replaced by the GS-PTV and the incidental dose to GS-L1 was measured. Dosimetric data were analysed with Kruskal-Wallis test. Plans were intensity modulated radiotherapy (IMRT)-based. P3 with 90° arm setup had statistically significant higher L1 dose across the board than P1 and P2, with the mean dose (Dmean) reaching clinical significance. Dmean of P1 and P2 was consistent with the literature (77.4% and 74.7%, respectively). The incidental dose depended mostly on L1 proportion included in the breast fields, underlining the importance of the setup, even in case of IMRT.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/03008916231196801

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