Carcinogenicity Assessment of Daprodustat (GSK1278863), a Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor
Author:
Affiliation:
1. GlaxoSmithKline R&D, Collegeville, PA, USA
2. Charles River Laboratories, Sherbrooke, Quebec, Canada
3. Charles River Laboratories, Senneville, Quebec, Canada
Abstract
Publisher
SAGE Publications
Subject
Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine
Link
http://journals.sagepub.com/doi/pdf/10.1177/0192623319880445
Reference59 articles.
1. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor–Prolyl Hydroxylase Inhibitor for Anemia
2. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.
3. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
4. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
5. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
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