The Toxicology of Interleukin-12: A Review

Author:

Car Bruce D.1,Eng Vicki M.2,Lipman Jack M.3,Anderson Timothy D.3

Affiliation:

1. Safety Assessment, DuPont Pharmaceuticals Company, Newark, Delaware 19714-0030, DuPont Pharmaceuticals, Stine-Haskell Research Center, Building 320, Newark, Delaware 19714-0030, .

2. Unit of Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania 19104

3. Department of Toxicology and Pathology, Hoffinan-La Roche, Nutley, New Jersey 07110

Abstract

Recombinant murine interleukin (IL)-12 (rmIL-12) exhibits antitumor, antiviral, and antimicrobial activities and can modify allergic inflammatory reactions in animal models. Recombinant human IL-12 (rhIL-12) is currently in clinical trials for treatment of cancer, asthma, and viral hepatitis. Principally a phagocyte-derived cytokine, IL-12 targets natural killer cells and T lymphocytes, stimulating their activity and the secretion of interferon (IFN)-γ. An understanding of the toxicology of IL-12, due in part to effects mediated by IFN-γ, has emerged from preclinical safety and mechanistic studies and initial clinical trials. Target organs common to several animal species and humans include the lymphohematopoietic system, intestines, liver, and lung.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

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