Forgetfulness: A Role in Noncompliance with Antidepressant Treatment

Abstract

Objectives: To determine the degree of noncompliance with antidepressant treatment in the Alberta population and to investigate the reasons for noncompliance. Method: We used data from the Alberta Mental Health Survey, a telephone survey conducted in 2003 ( n = 5323 adults), to produce population-based estimates of the frequency of noncompliance and the reported reasons for noncompliance. Results: Reported noncompliance was 41.7% (95% confidence interval [CI], 36.9% to 46.6%) for respondents taking 1, 2, or 3 antidepressants. Noncompliance for those taking 1 antidepressant was 42.0% (95%CI, 36.9% to 47.2%), whereas noncompliance for those taking 2 or 3 antidepressants was 39.4% (95%CI, 26.7% to 53.6%). Among respondents currently taking at least one antidepressant, 64.9% (95%CI, 57.4% to 71.7%) reported that forgetfulness was the most common reason for noncompliance. Of respondents taking 1 medication, 64.1% (95%CI, 56.0% to 71.4%) reported forgetfulness as did 71.3% (95%CI, 48.3% to 86.8%) of those taking 2 or 3 medications. Both the frequency of noncompliance and the reported reasons for noncompliance were independent of sex and age. Conclusion: Our study replicates prior reports that indicate that noncompliance is common with antidepressant treatment. Forgetting to take medication is the most important reported reason for this noncompliance.