Effect of menstrual status on lipid profile: A cross-sectional study in a tertiary care hospital in Nepal

Author:

Adhikaree Jasper1ORCID,Shrestha Ruyusha1,Bomjan Prabina1,Shrestha Ashmita1,Pokharel Shreya1,Acharya Rashila1,Siwakoti Anusha1,Pokhrel Ritesh1,Marzo Roy Rillera2,Rajbhandari Prachand Man Singh1ORCID,Acharya Swosti3

Affiliation:

1. Department of Medical Biochemistry, Nobel College, Pokhara University, Kathmandu, Nepal

2. Department of Community Medicine, International Medical School, Management and Science University, Shah Alam, Malaysia

3. Department of Nursing, Manmohan Cardiothoracic Vascular and Transplant Center, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal

Abstract

Background: The ovarian follicular cell's degradation and subsequent decrease in the synthesis of estrogen results in the decreased cardiovascular protection. As a result, the incidence of cardiovascular disease (CVD) increases in postmenopausal women and is characterized by change in lipid profile. This study sought to ascertain the extent of the impact that menstrual status might have on lipid profiles among premenopausal and postmenopausal women. Methods: A cross-sectional study was conducted with 260 premenopausal and postmenopausal women (1: 1) and serum lipid component concentrations (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), and total cholesterol (TC)) were measured. A comparison between two groups was made between premenopausal and postmenopausal women, and regression was carried out to estimate the effect of menstrual status on lipid components. Results: Compared with premenopausal women, the concentrations of the lipid components (HDL-C, LDL-C, TG, and TC) were found to be significantly higher in postmenopausal women. Using the linear regression, menstruation status was able to predict 11.7%–13.3% of the lipid components (TG and TC) when age and weight were adjusted. Conclusion: The difference in lipid components between premenopausal women and postmenopausal women exists, with menstrual status explaining 11.7%–13.3% variance for the observed lipid level. The factors influencing the lipid profile beside the menstrual status should also be explored. External intervention such as estrogen replacement therapy is also recommended in case of deviation of lipid profile from the suggested normal clinical range.

Funder

Nobel College, Pokhara University

Publisher

SAGE Publications

Subject

Obstetrics and Gynecology

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