Affiliation:
1. University of Health Sciences, Istanbul, Turkey
2. Bezmialem Vakif University, Istanbul, Turkey
3. Lokman Hekim University, Ankara, Turkey
Abstract
Objective: This study aims that oxidative stress and inflammation status in children and adolescents with attention deficit hyperactivity disorder (ADHD) compared to their healthy peers. Method: Thirty ADHD and healthy controls were included in this study. ADHD diagnosis according to the DSM-V and Conners’ teacher and parent rating scale by a structured psychiatric interview. Total oxidant status (TOS), total antioxidant status (TAS), and total and native thiol levels were determined using photometric methods. Presepsin, Interleukin (IL) 1-ß, IL-6, and Tumor Necrosis Factor-alpha (TNF-α) levels were measured with commercial ELISA kits. Results: We showed that TOS and oxidative stress index were significantly higher in the ADHD group, and TAS was lower than in the control group ( p<.001). Similarly, IL1-ß, IL-6, and TNF-α levels were statistically higher in the ADHD group. Backward LR regression analysis reveals that TOS and IL-6 predicted ADHD. Conclusion: TOS and IL-6 levels may play a role in the pathogenesis of ADHD.
Subject
Clinical Psychology,Developmental and Educational Psychology
Cited by
3 articles.
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