Effect of oral nutritional supplements on outcomes in children presenting with, or at risk of, faltering growth in clinical settings: A systematic review and meta-analysis

Author:

Cawood AL12,Smith C3,Kinnear FJ4ORCID,Upton L5,Trace S6,O’Connor G7ORCID,Stratton RJ12

Affiliation:

1. Institute of Human Nutrition, Faculty of Medicine, University of Southampton, Southampton, UK

2. Medical Affairs, Nutricia Ltd, Trowbridge, UK

3. Nutrition and Dietetics, Royal Alexandra Children’s Hospital, Brighton, UK

4. National Institute for Health and Care Research, Bristol Biomedical Research Centre, Bristol, UK

5. Nutrition and Dietetics, The Children’s Dietitian Ltd, Birmingham, UK

6. Nutrition and Dietetics, Bristol Royal Hospital for Children, Bristol, UK

7. Dietetics Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

Abstract

This systematic review summarises evidence regarding oral nutritional supplement (ONS) use in children with, or at risk of, faltering growth (FG). Ten randomised controlled trials (RCTs), compared changes in outcomes amongst children receiving ONS versus control were included. Overall, 1116 children (weighted mean (WM) age 5 years; n658 (59%) male) were recruited, of which 585 (52%) received ONS (WM intake contribution 412 kcal, 16.3 g protein, 395 ml) for 116 days (WM). ONS use was associated with significantly greater gains in weight (mean difference (MD) 0.4 kg, 95% CI [0.36, 0.44]) and height (MD 0.3 cm, 95% CI [0.03, 0.57]), likely related to improvements in nutritional intake. Mean compliance to prescribed dose was 98%. Data suggested an association between ONS use and reduced infections. Further research is warranted to establish ONS dosage and effects upon other outcomes. This review provides evidence to support use of ONS in the management of children with, or at risk of, FG.

Publisher

SAGE Publications

Subject

Pediatrics,Pediatrics, Perinatology and Child Health

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