Stress, mindfulness, and systemic lupus erythematosus: An overview and directions for future research

Author:

Molina Emily1ORCID,Gould Neda2,Lee Kristen3,Krimins Rebecca4,Hardenbergh Dylan5,Timlin Homa6

Affiliation:

1. Rheumatology Fellowship, Johns Hopkins University, Baltimore, MD, USA

2. Division of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA

3. Internal Medicine Residency, Northwestern University Hospitals, Chicago, IL, USA

4. Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA

5. Internal Medicine Residency, Columbia and Presbyterian Hospitals, NY, NY, USA

6. Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA

Abstract

Although the pathogenesis of autoimmunity is not fully understood, it is thought to involve genetic, hormonal, immunologic, and environmental factors. Stress has been evaluated as a potential trigger for autoimmunity and disease flares in patients with systemic lupus erythematosus (SLE). The physiologic changes that occur with stress involve numerous catecholamines, hormones, and cytokines that communicate intricately with the immune system. There is some evidence that these systems may be dysregulated in patients with autoimmune disease. Mindfulness-based techniques are practices aimed at mitigating stress response and have been shown to improve quality of life in general population. This review will discuss pathophysiology of chronic stress as it relates to SLE, evidence behind mindfulness-based practices in these patients, and directions for future research.

Publisher

SAGE Publications

Subject

Rheumatology

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