Myasthenic Crisis

Author:

Wendell Linda C.1,Levine Joshua M.2

Affiliation:

1. Department of Neurology, University of Pennsylvania, Philadephia, PA

2. Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA

Abstract

Myasthenic crisis is a complication of myasthenia gravis characterized by worsening of muscle weakness, resulting in respiratory failure that requires intubation and mechanical ventilation. Advances in critical care have improved the mortality rate associated with myasthenic crisis. This article reviews the epidemiology of myasthenic crisis and discusses patient evaluation. Therapeutic options including mechanical ventilation and pharmacological and surgical treatments are also discussed.

Publisher

SAGE Publications

Subject

Clinical Neurology

Reference60 articles.

1. Ropper AH, Gress DR, Diringer MN, Green DM, Mayer SA, Bleck TP. Treatment of the Critically Ill Patient With Myasthenia Gravis. Neurological and Neurosurgical Intensive Care. 4th ed. Philadelphia, PA: Lipincott Williams & Wilkins; 2004:299–311.

2. Myasthenia gravis

3. Myasthenic crisis

4. Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis

5. On the Concept of Myasthenic Crisis

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