Effects of anti-osteoporosis therapy on plasma aldosterone and renin

Author:

Hu Qingfen1,Liao Kangla2,Zhang Longwei1,Shu Xiaoyu3,Xu Zhixin4ORCID,Qiu Yuyang15,Li Qifu4,Yang Shumin4

Affiliation:

1. Department of Endocrinology, the People’s Hospital of Kaizhou District, PR China

2. Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, PR China

3. Department of Endocrinology, the Affiliated Hospital of Guizhou Medical University, PR China

4. Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, PR China

5. Department of Emergency, the Second People’s Hospital of Guiyang, PR China

Abstract

Objective: This study aimed to investigate the effect of anti-osteoporosis therapy on plasma aldosterone concentration (PAC), plasma renin concentration (PRC) and the aldosterone/renin ratio (ARR) in patients with postmenopausal osteoporosis. Methods: In 60 patients with postmenopausal osteoporosis, bone mineral density (BMD), PAC and PRC were measured before and after treatment with alendronate (70 mg/week, n=22) or recombinant human parathyroid hormone (20 μg/day, n=35) for 48 weeks. Results: PAC was negatively correlated with the T-score of lumbar spine BMD and femoral neck BMD (lumbar r=−0.386, p<0.01; femoral neck r=−0.262, p<0.05). With the improvement in lumbar BMD after anti-osteoporosis treatment (T-score −3.4±0.5 vs. –3.1 ±0.4, p<0.0001), PAC decreased from 182.8±53.2 to 143.7±68.6 pg/mL ( p<0.0001), PRC increased from 7.8±11.6 to 39.2±50.0 μIU/mL ( p<0.0001) and the ARR decreased from 74.8±75.2 to 13.1±17.1 pg/μIU ( p<0.0001). At baseline, 58% (35/60) of the patients had an ARR >37 pg/μIU, and the proportion decreased to 8% (5/57) after treatment. Conclusion: Treatment with alendronate or parathyroid hormone causes decreased PAC and increased PRC, resulting in a decreased ARR in postmenopausal women with osteoporosis.

Funder

The National Natural Science Foundation of China

National key research & development plan, major project of precision medicine research

Joint Research Project of Chongqing Science and Technology Commission and Traditional Chinese Medicine

Publisher

Hindawi Limited

Subject

Endocrinology,Internal Medicine

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