Antimycobacterial Activity of Milemaronol, a New Squalene-Type Triterpene, and Other Isolate?-Reference-Cited by-同舟云学术

Antimycobacterial Activity of Milemaronol, a New Squalene-Type Triterpene, and Other Isolate?

Published:2020-05 Issue:5 Volume:15 Page:1934578X2092558
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Boeno Samyra I. S.¹,Passos Michel de S.¹,Félix Mariana¹,Calixto Sanderson D.²,Júnior Almir R. C.³,Barbosa Siqueira Lara F.⁴,Muzitano Michelle F.⁵,Braz-Filho Raimundo¹⁶,Vieira Ivo J. Curcino¹

Affiliation:

1. Setor de Química de Produtos Naturais, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil

2. Laboratório de Biologia do Reconhecer, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil

3. Instituto Federal de Santa Catarina, Campus Criciúma, SC, Brazil

4. Instituto Federal Fluminense, Campus Centro, Campos dos Goytacazes, RJ, Brazil

5. Laboratório de Produtos Bioativos (LPBio), Curso de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Campus Dr. Aloisio Teixeira, Macae, RJ, Brazil

6. FAPERJ/Departamento de Química, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, Brazil

Abstract

A new triterpene, named milemaronol (1), was isolated from Homalolepis suffruticosa Engl., Simaroubaceae, along with 10 known metabolites, chaparrinone (2), scopoletin (3), 5-methoxycanthin-6-one (4), eurylene (5), hispidol A (6), hispidol B (7), nilocitine (8), α-dihydronylocytine (9), β-dihydronylocytine (10), and teurilene (11). These compounds were characterized based on their spectral data, mainly 1D (1H, 13C-APT) and 2D (1H-1H-COSY, NOESY, HSQC, HMBC) NMR and their mass spectra (HR-ESI-MS), in comparison with data from the literature. Compounds 1 to 6, 8, and 9 were evaluated for their antimycobacterial activity against 2 strains (H37Rv and M299).

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20925589

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