Effects of a <i>Cordyceps militaris</i> With <i>Herba epimedii</i> Complex on Chronic Renal Failure Induced by Adenine in vivo-Reference-Cited by-同舟云学术

Effects of a Cordyceps militaris With Herba epimedii Complex on Chronic Renal Failure Induced by Adenine in vivo

Published:2022-06 Issue:6 Volume:17 Page:1934578X2211053
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Ma Changyang¹²,Wang Xuebiao¹,Shao Wenjing¹,Zhao Qingchun¹,Wei Jinfeng¹³⁴,Liu Zhenhua¹²,Li Changqin¹²³

Affiliation:

1. National R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng, China

2. Joint International Research Laboratory of Food & Medicine Resource Function of Henan Province, Kaifeng, China

3. Functional Food Engineering Technology Research Center of Henan Province, Kaifeng, China

4. Technology & Media University of Henan Kaifeng, Kaifeng, China

Abstract

In this paper, the relieving effects of Cordyceps militaris and Herba epimedii complex on chronic renal failure (CRF) induced by adenine were investigated. The CRF model with severe damage to kidney tissue and abnormality of physiological and biochemical indices was established by administrating Sprague Dawley male rats daily with adenine (250 mg/kg). After treatments with the complex, the levels of serum creatinine ( P < .001), urea nitrogen ( P < .001), uric acid ( P < .001), and P3+ ( P < .01) were significantly decreased, while the levels of estradiol (E2), luteinizing hormone ( P < .001), nitrite oxide ( P < .001), and Ca2+ ( P < .001) were significantly increased. The damage to kidney tissue of CRF rats was obviously ameliorated. All the treatment groups showed therapeutic effects of CRF induced by adenine. The Cordyceps militaris and Herba epimedii complex showed the best effect at the dose of 10.4 + 10.4 mg/kg/d.

Funder

Key Science and Technology Project for Universities of Henan Province

Key Project in Science and Technology Agency of Henan Province

Major Public Welfare Projects in Henan Province

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X221105373

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