Synthesis and Antimicrobial Activities of 3-Methyl-β-Carboline Derivatives-Reference-Cited by-同舟云学术

Synthesis and Antimicrobial Activities of 3-Methyl-β-Carboline Derivatives

Published:2015-06 Issue:6 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Zhang Jiwen¹²,Li Longbo¹,Dan Wenjia¹,Li Jian¹,Zhang Qianliang¹,Bai Hongjin²,Wang Junru¹

Affiliation:

1. College of Sciences and Institute of Pesticide, Northwest A&F University, Yangling, Shaanxi 712100, China

2. Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China

Abstract

The β-carboline alkaloids possess a diverse range of important biochemical effects and pharmacological properties. Sixteen 3-methyl-β-carboline derivatives were synthesized from indole formaldehyde and nitroethane via the Henry reaction, LAH/THF reduction, the Pictet-Spengler reaction and Pd/C/xylene oxidation, including four 1-substituted and twelve 9-substituted 3-methyl- β-carboline derivatives. The structures of all the derivatives were confirmed by 1H NMR, 13C NMR and ESI-MS. Most of these 3-methyl-β-carboline derivatives showed some antibacterial activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000627

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