(+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity-Reference-Cited by-同舟云学术

(+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity

Published:2015-10 Issue:10 Volume:10 Page:1934578X1501001
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Novák Zdeněk¹,Hošt'álková Anna²,Opletal Lubomir²,Nováková Lucie³,Hrabinová Martina⁴,Kuneš Jiři¹,Cahliková Lucie²

Affiliation:

1. Department of Inorganic and Organic Chemistry, Charles University, Heyrovského 1203, 500 05 Hradec Kralové, Czech Republic

2. ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Heyrovského 1203, 500 05 Hradec Kralové, Czech Republic

3. Department of Analytic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Kralové, Czech Republic

4. Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Třebesšká 1575, 500 05 Hradec Králové, Czech Republic

Abstract

A known alkaloid (+)-chenabinol (1) and two new secobisbenzylisoquinoline alkaloids were isolated by standard chromatographic methods from the root bark of Berberis vulgaris L. The structures of the new alkaloids, named berkristine (2) and verfilline (3), were established by spectroscopic (including 2D NMR), and HRMS (ESI) methods. The alkaloids were tested for their inhibition activity of human cholinesterases and prolyl oligopeptidase. Compound 1 inhibited human butyrylcholinesterase with an IC50 value of 44.8 ± 5.4 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501001015

Reference8 articles.

1. Berbanine: A New Isoquinoline-Isoquinolone Alkaloid from Berberis Vulgaris (Berberidaceae)

2. Deuterium isotope effects on 13C and 15N chemical shifts of intramolecularly hydrogen-bonded enaminocarbonyl derivatives of Meldrum’s and Tetronic acid

3. Berbidine: A Simple Isoquinoline-Isoquinolone Dimer

4. Chenabine and Jhelumine: Secobisbenzylisoquinolines or Simple Isoquinoline-Benzylisoquinoline Dimers?

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