Affiliation:
1. School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China
Abstract
Callicarpa giraldii (family Verbenaceae) has many medical properties and is commonly used in traditional Chinese medicine. However, its chemical constituents have not been investigated. In this study, nine compounds present in the leaves and stems were isolated and characterized. These were negundonorin B (1), lupeol (2), erythrodiol (3), isoacteoside (4), forsythoside B (5), dibutyl phthalate (6), verbascoside (7), poliumoside (8), and 3-methoxy-4-hydroxybenzaldehyde (9). The structures were identified by comparison of their NMR data with those reported in the literature. The anti-inflammatory effects of compounds 1-6 were tested on lipopolysaccharide-stimulated RAW264.7 macrophages. Several compounds showed significant ( p < .05) inhibitory effects.
Funder
Science and Technology Planning Project of Guangdong Province of China
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Reference19 articles.
1. Editorial Committee of the Flora of China, Chinese Academy of Sciences. Flora of China. Science Press; 1999:65(1):25.
2. Wang HG. Study of chemical constituents and anti-inflammatory activity of two medical plant of callicarpa genus. dissertation. Guangzhou University of Chinese Medicine; 2019.
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