Heptacyclosordarianone, a New Polyketide From Sordaria sp., an Endophytic Fungus From Garcinia polyantha-Reference-Cited by-同舟云学术

Heptacyclosordarianone, a New Polyketide From Sordaria sp., an Endophytic Fungus From Garcinia polyantha

Published:2020-12 Issue:12 Volume:15 Page:1934578X2097762
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Tsague Tankeu Virginie Flaure¹²,Sema Denis Kehdinga¹²³,Jouda Jean-Bosco⁴,Tatsimo Simplice Joel N.²,Ntonga Patrick Akono⁵,Wansi Jean Duplex⁶,Fogue Simeon Kouam⁷,Loura Benoît⁸,Shiono Yoshihito⁹,Sewald Norbert³,Lannang Alain Meli²³⁴^ORCID

Affiliation:

1. Faculty of Science, Department of Chemistry, University of Maroua, Maroua, Cameroon

2. Department of Chemistry, Higher Teachers’ Training College, University of Maroua, Maroua, Cameroon

3. Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany

4. Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Ngaoundere, Cameroon

5. Faculty of Sciences, Department of Animal Biology, University of Douala, Douala, Cameroon

6. Faculty of Sciences, Department of Chemistry, University of Douala, Douala, Cameroon

7. Department of Chemistry, Higher Teachers’ Training College, University of Yaoundé, Yaoundé, Cameroon

8. Department of Leather and Textile Engineering, National Polytechnic Institute, University of Maroua, Cameroon

9. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Yamagata, Japan

Abstract

One new polyketide derivative, heptacyclosordarianone (1), together with 2 known compounds, heptacyclosordariolone (2) and sordariol (3), were isolated from an extract of Sordaria sp. AM-71, an endophytic fungus inhabiting Garcinia polyantha. The structures of these compounds were elucidated based on intensive nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry and by comparison with literature data. All compounds were assayed for their antimicrobial and cytotoxic properties. Only compound 2 showed antimicrobial activities against Bacillus subtilis DSMZ 704 , Pseudomonas agarici DSMZ 11810, and Micrococcus luteus DSMZ 1605 with minimum inhibitory concentration values of 9.3, 15.5, and 16.9 µg/mL respectively. None of the isolated compounds showed a significant cytotoxic property.

Funder

Deutscher Akademischer Austausch Dienst Kairo

Alexander von Humboldt-Stiftung

Academy of Sciences for the Developing World

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20977622

Reference17 articles.

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