Cytotoxic Sesquiterpenoids From Soft Soral Capnella imbricata-Reference-Cited by-同舟云学术

Cytotoxic Sesquiterpenoids From Soft Soral Capnella imbricata

Published:2019-06 Issue:6 Volume:14 Page:1934578X1985749
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Phan Chin-Soon¹,Kamada Takashi²,Ishii Takahiro³,Hamada Toshiyuki⁴,Vairappan Charles Santhanaraju¹

Affiliation:

1. Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia

2. Laboratory of Natural Products Chemistry, Department of Materials and Life Science, Faculty of Science and Technology, Shizuoka Institute of Science and Technology, Fukuroi, Shizuoka, Japan

3. Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Nishihara, Okinawa, Japan

4. Graduate School of Science and Engineering, Kagoshima University, Kagoshima, Japan

Abstract

A new sesquiterpene, capgermacrene H (1) was isolated together with 7 other compounds, capgermacrenes A-G (2-8), from a population of soft coral Capnella imbricata collected from Mantanani Island, Sabah, Malaysia. The structure of this metabolite was elucidated based on spectroscopic data such as nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry. Capgermacrene A (2) showed potent cytotoxicity against adult T-cell leukemia, S1T cells at half-maximal inhibitory concentration of 0.79 µg/mL.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X19857494

Reference10 articles.

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2. Anti-Inflammatory Activities of Natural Products Isolated from Soft Corals of Taiwan between 2008 and 2012

3. Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

4. Capgermacrenes D-G, new sesquiterpenoids from a Bornean soft coral, Capnella imbricata

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