Two New Terpenoids From the Fruits of Chaenomeles sinensis (Thouin) Koehne-Reference-Cited by-同舟云学术

Two New Terpenoids From the Fruits of Chaenomeles sinensis (Thouin) Koehne

Published:2021-02 Issue:2 Volume:16 Page:1934578X2199615
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Li Meng¹²^ORCID,Zhang Zhi-guang¹²³,Shi Jing-ya¹²,Li Ya-ge¹²,Zhang Jing-ke¹²,Ying Yang¹²,Deng Xiao-yan¹²,Zheng Xiao-ke¹²,Feng Wei-sheng¹²

Affiliation:

1. Henan University of Chinese Medicine, Zhengzhou, China

2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, China

3. School of Pharmacy, Minzu University of China, Beijing, China

Abstract

A new sesquiterpenoid, chaenomelesterpenoid A (1), and a new norisoprenoid, chaenomelesterpenoid B (2), were isolated from the fruits of Chaenomeles sinensis (Thouin) Koehne. Their structures were determined by NMR spectroscopy and MS. In addition, the protective effects of the compounds were tested against corticosterone-induced damage in PC-12 cells using real-time cellular analysis (RTCA). Compounds 1 and 2 significantly improved cell viability and corticosterone-induced damage in PC-12 cells with EC50 values of 15.7 and 12.6 µM, respectively.

Funder

national key research and development program of china

the Central Government Guide Local Science and Technology Development Funds

key scientific research project of colleges and universities in henan province

and the Special Project of Scientific Research on Traditional Chinese Medicine in Henan

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X21996153

Reference16 articles.