Update on Management and Outcomes of Congenital Diaphragmatic Hernia

Author:

Wild K. Taylor1ORCID,Hedrick Holly L.23,Ades Anne M.1,Fraga Maria V.1,Avitabile Catherine M.4,Gebb Juliana S.2,Oliver Edward R.5,Coletti Kristen1,Kesler Erin M.3,Van Hoose K. Taylor3,Panitch Howard B.6,Johng Sandy1,Ebbert Renee P.3,Herkert Lisa M.3,Hoffman Casey7,Ruble Deanna2,Flohr Sabrina2,Reynolds Tom2ORCID,Duran Melissa3ORCID,Foster Audrey8,Isserman Rebecca S.9,Partridge Emily A.23,Rintoul Natalie E.1

Affiliation:

1. Division of Neonatology, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA

2. Richard D. Wood Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA, USA

3. Division of Pediatric General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA

4. Division of Cardiology, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA

5. Department of Radiology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

6. Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA

7. Department of Child and Adolescent Psychiatry and Behavioral Sciences, The Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA

8. Department of Clinical Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA

9. Division of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA

Abstract

Infants with congenital diaphragmatic hernia (CDH) benefit from comprehensive multidisciplinary teams that have experience in caring for the unique and complex issues associated with CDH. Despite prenatal referral to specialized high-volume centers, advanced ventilation strategies and pulmonary hypertension management, and extracorporeal membrane oxygenation, mortality and morbidity remain high. These infants have unique and complex issues that begin in fetal and infant life, but persist through adulthood. Here we will review the literature and share our clinical care pathway for neonatal care and follow up. While many advances have occurred in the past few decades, our work is just beginning to continue to improve the mortality, but also importantly the morbidity of CDH.

Publisher

SAGE Publications

Subject

Critical Care and Intensive Care Medicine

Reference124 articles.

1. Congenital Diaphragmatic Hernia

2. Epidemiology and Prognosis of Congenital Diaphragmatic Hernia: A Population-Based Cohort Study in Utah

3. Mortality in Congenital Diaphragmatic Hernia

4. Hedrick HL, Adzick NS. Congenital diaphragmatic hernia in the neonate. In: UpToDate, Garcia-Prats (Ed), UptoDate, Waltham, MA, 2023.

5. Extracorporeal Life Support Organization (ELSO) Registry Report. International Summary. October, 2021.

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