ABO blood group and risk of pre-eclampsia. A case-control study

Abstract

Background It appears that some ABO blood groups may be a risk factor for venous thrombosis. The association between ABO group and risk of pre-eclampsia remains controversial. The purpose of this study was to evaluate the relationship between pre-eclampsia and ABO groups. Methods A retrospective case-control (1:2) study in a prospective monocentric registry including 20171 pregnancies was performed. Women with pre-eclampsia and severe pre-eclampsia were identified. Controls were matched according to age, parity, year of delivery and body mass index. Blood groups were considered. Results Two hundred fifty-three cases and 506 controls were included. No difference in distribution was found between cases and controls for non-O group (57.51% vs 62.56, p : 0.19), group A (39.92% vs 44.05, p : 0.29), group B (13.83% vs 15.42, p : 0.57) group AB (3.75 vs 3.08, p : 0.64). The analysis extended to severe pre-eclampsia showed no difference. Conclusion This study did not document any relationship between ABO groups and the risk of preeclampsia.